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1. An informal, colloquial greeting (a contraction of "how do you do?"). Well hey, Bob, how-d'ye-do? Been a long time since I've seen you around here!
2. An unfortunate, unpleasant, or awkward situation or circumstance; a troublesome or difficult state of affairs. (Often phrased as "a fine how-d'ye-do.") Well that's a fine how-d'ye-do. I'm on the job for just two days and I find out that the company is going bankrupt!