Next, Freedman's team followed the lead of other researchers who had shown that clonidine, a common high-blood-pressure drug, reduced hot flashes in some women.
The Michigan researchers found clonidine indeed decreased the number of hot flashes experienced among these women -- from eight during the saline-only infusion to just two among women receiving clonidine treatment.
These findings suggest yohimbine triggers hot flashes among susceptible women by spurring neurons in the hypothalamus to release norepinephrine, Freedman says.
The exclusive sublicense agreement with PharmaNova relates to the use of gabapentin for the treatment of menopausal hot flashes covered by U.
Pelzel continued, "The market for hot flashes is sizeable and characterized by a significant unmet need because women and their doctors have increasingly shied away from traditional hormonal, or estrogen, therapies.
The use of estrogen for hot flashes was challenged when results of an NIH-sponsored Women's Health Initiative trial were published in the July 2002 issue of JAMA, demonstrating that hormone replacement therapy significantly increased risk of coronary heart disease and stroke.
But a magnetic mechanism might not provide enough energy to account for the biggest flashes Schaefer lists.
Canadian researchers recorded some spectacular flashes in the direction of the constellation Perseus several years ago.
One thing that might speed up the search is a project to systematically watch for flashes.
The MR-14EX requires 4 AA-size batteries and is equipped with a socket for optional external power supplies such as the Canon Compact Battery Pack CP-E2 to reduce recycling time and increase the number of flashes
per set of batteries.
Tripods new dynamic Info Flashes is the first such service that gives homepage builders the flexibility to choose, personalize and publish news and content in a homepage they design themselves," said Scott Walker, Tripod's vice president of marketing.
Tripods Info Flashes can be easily added to new or existing homepages using Tripods Homepage Studio (http://www.
Specially designed icons can be included with the Weather and Horoscope Info Flashes.