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Currently traveling to someone or something. We're en route to the party and should be there in five minutes. It looks like the package is en route and should arrive today.
In one group or body; all together. For example, The activists marched en masse to the capitol. This French term, with exactly the same meaning, was adopted into English about 1800.
On or along the way, as in We'll pick up Dan en route to the restaurant, or We can finish our discussion en route. This French term was adopted into English in the late 1700s.