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in the depths of (something)
In the middle of and wholly consumed by a particularly negative and/or difficult situation or emotional state. The country was in the depths of the worst economic disaster of the last century. While I was in the depths of depression, I found that I couldn't even get out of bed in the morning.
despair of (something)
To view a situation as hopeless. Considering her dire diagnosis, I despaired of grandma ever regaining her health.
drive (one) to despair
To cause one to experience sadness, hopelessness, and/or frustration. I'm not surprised that his wife's death has driven him to despair—grief has that effect on people. Try not to let this rejection drive you to despair.
despair of something
to give up all hope of something. Do not despair of his returning; I think we will see him again. I despair of ever seeing her again.
drive someone to despair
Fig. to depress someone; to frustrate someone. Sometimes raising an infant drives me to despair! The recent problems drove her to despair.
sink into despair
to become depressed; to become completely discouraged. After facing the hopelessness of the future, Jean Paul sank into despair. Mary sank into despair upon learning of the death of her grandmother.
To lose all hope for something or someone: The shipwrecked sailors despaired of being rescued. I have seen so much unfairness that I despair of a just world.