1. A moment when one chooses to accept Jesus Christ as one's savior and follow the Christian faith. I had something of a come-to-Jesus moment after my car crash last month.
2. A moment of epiphany, enlightenment, or intuition regarding the truth of a matter. I had something of a come-to-Jesus moment after college when I realized that I wanted to be an editor for a living.
3. A point in time in which fundamental priorities and/or beliefs are challenged, reassessed, or reaffirmed. After waking up in the hospital from a drug overdose, I had a frightening come-to-Jesus moment about what I was doing with my life. The political party needs to have a real come-to-Jesus moment and decide who they are and what they stand for as a whole.
4. Any moment or meeting in which a frank, often unpleasant, conversation is held so as to bring to light and/or resolve some issue at hand. Boys, we're going to have a come-to-Jesus moment about the drugs I found in the house, and if no one tells me the truth then you're both going to get a whooping. The boss called us in for a real come-to-Jesus moment about our sales for this quarter.
See also: moment