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1. Something that has gone awry or not as one expected, with the implication that it is the product of bad luck. I can't believe you didn't get that part in the play. What a bad break. Shelly had a bad break this morning when her car wouldn't start.
2. A fracture of a bone that is particularly extreme or not conducive to proper healing. Unfortunately it was a bad break, and your leg will have to be in a cast for six months.