Exposure to very low doses of endocrine disrupting chemicals (EDCs) during fetal life permanently alters brain development and behavior in animals and humans.
Realizing that something other than cholinesterase inhibition was affecting the fetus, a team from Duke University led by Theodore Slotkin gradually began to demonstrate that other mechanisms of action of CPF alter prenatal development of the brain and behavior and that the embryo and fetus are sensitive to cholinesterase inhibition at doses that would not be toxic to an adult (Qiao et al.
2002) confirmed the ability of CPF to alter the activity of another nuclear transcription factor in cortical neurons, the [Ca.
There are numerous opportunities during gestation where insecticides and products from several other chemical classes can alter the purpose of a cell, tissue, organ, or system function in the brain or CNS, much like the discoveries presented for CPF.
Other factors alter
the color of hair samples, too, reports Wis-Surel.
Our data indicate not only that acute exposure to these environmental estrogens induces deleterious effects on early vertebrate development but also that different environmental estrogens may alter the fate of a specific cell type via different mechanisms.
Endogenous and environmental estrogens have been shown to alter apoptosis; however, most studies demonstrating effects of environmental estrogens have been performed on cell lines, and some of the studies that have been performed on intact embryos indicate the effects of these toxicants are limited to reproductive tissues (Weber et al.
Previous studies have demonstrated that environmental estrogens alter apoptosis in breast cancer cell lines (Diel et al.
Concentrations of a common toxicant too low to cause reproductive abnormalities can still alter behavior in rats, according to a team of researchers led by Vincent Markowski of the University of Southern Maine in Portland [EHP 109:621-627].
Environmental Protection Agency at 13 ng/kg--was high enough to alter rats' behavior; the researchers extrapolated that a 10% change in the rats' behavior was noted at maternal TCDD exposures of 7-8 ng/kg.
The meeting was convened to guide future research by applying this knowledge of calcium channel biology to further our understanding of how toxicants and mutations alter channel functions.
There are two fundamentally different mechanisms whereby neurotoxicants might alter calcium channel function: by direct interaction with channel subunits (e.
Some non-coplanar PCBs impair the function of the ryanodine receptor and alter intracellular calcium regulation.
Recent electrophysiologic experiments in embryonic kidney cells transfected with FHM genes show that the mutated genes alter channel kinetics.