screw (one) up in the head

To cause one to become mentally unwell or unstable. Possibly offensive. Tim has been behaving very erratically lately. I'm worried that the accident screwed him up in the head. Oh, grief can screw somebody up in the head, for sure. Healing after the death of a loved one is a slow process.

screwed up in the head

Mentally unwell or unstable. Possibly offensive; often used hyperbolically. Tim has been behaving very erratically lately. I'm afraid he got screwed up in the head because of the accident. Oh, Liz is screwed up in the head if she thinks that plan will work!