drive (oneself) into the ground

To work oneself to the point of illness or exhaustion. If you keep working 80-hour weeks, you'll drive yourself into the ground sooner than later. I drove myself into the ground pulling all-nighters in graduate school. There's just no other way to keep up with all the reading! You need to take a vacation from this place before you drive yourself into the ground.

drive/run/work yourself into the ˈground

work so hard that you become extremely tired: You need to be careful, or you’ll run yourself into the ground before long. ♢ With only two or three hours’ sleep a night, he was driving himself into the ground.