be sick and tired of (someone or something)

To be exceedingly wearied by, bored of, or exasperated with someone or something. I'm so sick and tired of doing my boss's errands. If something doesn't change soon, I'm going to quit! I was all gung-ho about this graduate program when I first began, but I must admit that I've been sick and tired of these boring lectures lately. A: "Chris made another disgusting remark during the lunch break again today." B: "I'm sick and tired of that guy! When will he learn that we don't think that crap is funny?"