(one's) get-up-and-go got up and went

informal One's positivity, energy, ambition, or determination has deteriorated or feels nonexistent. A: "Are you all right? It looks like your get-up-and-go got up and went!" B: "Oh, it definitely has—the baby's kept us up every night this week." I'm 89 years old, sonny! My get-up-and-go got up and went a long time ago. My get-up-and-go got up and went and no amount of coffee can bring it back, it seems.